Aethiopinone, an Antibacterial and Cytotoxic Agent from Salvia aethiopis Roots
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چکیده
منابع مشابه
Antibacterial and cytotoxic xanthones from the roots of Cratoxylum formosum.
Chemical investigation of the roots of Cratoxylum formosum has resulted in the isolation and characterization of xanthones: three new, named formoxanthone A-C and three known together with three known anthraquinones. Their structures were established on the basis of analysis of spectroscopic evidence. In addition, antibacterial and cytotoxic activities of the isolates were also evaluated.
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Four diterpenoids, ferruginol, salvipisone, aethiopinone and 1-oxoaethiopinone, were isolated from transformed roots of Salvia sclarea. Salvipisone and aethiopinone showed relatively high cytotoxicity against HL-60 and NALM-6 leukemia cells (IC50 range 0.6-7.7 microg/ mL which is equal to 2.0-24.7 microM), whereas 1-oxoaethiopinone and ferruginol were less active in this regard. Moreover, we ha...
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Five new iridoids, salvialosides A-E (compounds 1-5), together with fifty known compounds were isolated from the roots of Salvia digitaloides. The structures of the new compounds were completely elucidated using a combination of 2D NMR techniques (COSY, NOESY, HMQC and HMBC) and HR-ESI-MS analyses. The known compounds were identified by comparison of their spectroscopic and physical data with t...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 1999
ISSN: 1388-0209,1744-5116
DOI: 10.1076/phbi.37.1.17.6321